Clinicopathological profile of non-hodgkin lymphomas affecting the parotid glands

Gabriela Ribeiro De Araujo; Ana Luísa Morais-Perdigão; Lucas Ambrósio Lima; Cinthia Verónica Bardález Lopez de Cáceres; Juan Manuel Arteaga Legarrea; Nathalia Rodrigues Gomes; Pablo  Agustin Vargas; Elena María José Roman Tager; Hélder Antônio Rebelo Pontes; Ricardo Alves Mesquita; Silvia Ferreira de Sousa; Felipe Paiva Fonseca

doi:10.5327/2525-5711.247

Authors

Gabriela Ribeiro De Araujo Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0002-9232-906X
Ana Luísa Morais-Perdigão Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0003-4461-7531
Lucas Ambrósio Lima Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0003-0013-2962
Cinthia Verónica Bardález Lopez de Cáceres Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0002-9032-2067
Juan Manuel Arteaga Legarrea Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0003-4637-4617
Nathalia Rodrigues Gomes Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0003-4198-3042
Pablo Agustin Vargas Universidade Estadual de Campinas, Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0003-1840-4911
Elena María José Roman Tager Universidade Estadual de Campinas, Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0003-0891-9284
Hélder Antônio Rebelo Pontes Universidade Federal do Pará, Oral Pathology – Belém (PA), Brazil. https://orcid.org/0000-0002-7609-8804
Ricardo Alves Mesquita Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0003-3207-4007
Silvia Ferreira de Sousa Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0001-7820-4749
Felipe Paiva Fonseca Universidade Federal de Minas Gerais, Pathology – Belo Horizonte (MG), Brazil. https://orcid.org/0000-0002-6657-4547

DOI:

https://doi.org/10.5327/2525-5711.247

Keywords:

Lymphoma, MALT lymphoma, Follicular lymphoma, Sjogren’s syndrome, Parotid gland

Abstract

Objetivo: The aim of this study is to investigate the clinicopathological and immunohistochemical features of a series of lymphomas involving the parotid glands. Methods: All cases diagnosed in one pathology service from January 2008 and December 2018 were retrospectively retrieved, and the formalin-fixed paraffin-embedded tissue blocks were assessed for diagnostic confirmation. Clinical data were obtained from patients’ medical files. Results: We obtained twelve cases of NHL in the parotid glands representing nine MALT lymphomas, two follicular lymphomas (FL), and one diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). There was a predilection for the female sex (10F:2M), and in all cases it was possible to confirm the involvement of the parotid glands by macroscopic evaluation, imaging studies, or histologic assessment. Clinically, most of the lesions presented as asymptomatic swellings in the parotid region, although associated pain was reported in one case of FL, and three patients with MALT lymphoma had sicca symptoms. Conclusion: In conclusion, NHL affecting the parotid glands are usually of mature B cell lineage, usually representing low-grade subtypes, and frequently simulate other benign or malignant conditions.

References

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Geneva: WHO; 2017.

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. https://doi.org/10.3322/caac.21660

Iversen L, Eriksen PRG, Andreasen S, Clasen-Linde E, Homøe P, Wessel I, et al. Lymphoma of the sublingual gland: clinical, morphological, histopathological, and genetic characterization. Front Surg. 2020;7:581105. https://doi.org/10.3389/fsurg.2020.581105

Barnes L, Myers EN, Prokopakis EP. Primary malignant lymphoma of the parotid gland. Arch Otolaryngol Head Neck Surg. 1998;124(5):573-7. https://doi.org/10.1001/archotol.124.5.573

Araújo GR, Morais-Perdigão AL, Lopez-de-Cáceres CV, Almeida OP, Vargas PA, Roman-Tager EM, et al. Lymphomas affecting the submandibular glands. Med Oral Patol Oral Cir Bucal. 2024;29(1):e78-e86. https://doi.org/10.4317/medoral.26065

Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med. 2004;164(12):1275-84. https://doi.org/10.1001/archinte.164.12.1275

De Vita S, Isola M, Baldini C, Goules AV, Chatzis LG, Quartuccio L, et al. Predicting lymphoma in Sjögren's syndrome and the pathogenetic role of parotid microenvironment through precise parotid swelling recording. Rheumatology (Oxford). 2023;62(4):1586-93. https://doi.org/10.1093/rheumatology/keac470

Johnsen SJ, Brun JG, Gøransson LG, Småstuen MC, Johannesen TB, Haldorsen K, et al. Risk of non-Hodgkin's lymphoma in primary Sjögren's syndrome: a population-based study. Arthritis Care Res (Hoboken). 2013;65(5):816-21. https://doi.org/10.1002/acr.21887

Miyagi T, Nagasaki A, Taira T, Shinhama A, Suzuki M, Ohshima K, et al. Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma. 2009;50(2):187-95. https://doi.org/10.1080/10428190802702383

Gleeson MJ, Bennett MH, Cawson RA. Lymphomas of salivary glands. Cancer. 1986;58(3):699-704. https://doi.org/10.1002/1097-0142(19860801)58:3<699::aid-cncr2820580317>3.0.co;2-e

Mantsopoulos K, Koch M, Fauck V, Schinz K, Schapher M, Constantinidis J, et al. Primary parotid gland lymphoma: pitfalls in the use of ultrasound imaging by a great pretender. Int J Oral Maxillofac Surg. 2021;50(5):573-8. https://doi.org/10.1016/j.ijom.2020.08.008

Fox RI. Sjögren’s syndrome. Lancet. 2005;366(9482):321-31. https://doi.org/10.1016/S0140-6736(05)66990-5

De Vita S, Gandolfo S. Predicting lymphoma development in patients with Sjogren’s syndrome. Expert Rev Clin Immunol. 2019;15(9):929-38. https://doi.org/10.1080/1744666X.2019.1649596

Hansen A, Lipsky PE, Dörner T. B cells in Sjogren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue. Arthritis Res Ther. 2007;9(4):218. https://doi.org/10.1186/ar2210

Sandhya P, Kurien BT, Danda D, Scofield RH. Update on pathogenesis of Sjogren’s syndrome. Curr Rheumatol Rev. 2017;13(1):5-22. https://doi.org/10.2174/1573397112666160714164149

Bende RJ, Janssen J, Beentjes A, Wormhoudt TAM, Wagner K, Haacke EA, et al. Salivary gland mucosa-associated lymphoid tissue-type lymphoma from Sjogren’s syndrome patients in the majority express rheumatoid factors affinity-selected for IgG. Arthritis Rheumatol. 2020;72(8):1330-40. https://doi.org/10.1002/art.41263

Zucca E, Bertoni F, Cavalli F. Pathogenesis and treatment of extranodal lymphomas: the fascinating model of mucosa-associated lymphoid tissue lymphoma. Haematologica. 2003;88(8):841-4. PMID: 12935971.

Nakamura S, Ponzoni M. Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches. Pathology. 2020;52(1):15-29. https://doi.org/10.1016/j.pathol.2019.08.012

Zabotti A, Callegher SZ, Lorenzon M, Pegolo E, Scott CA, Tel A, et al. Ultrasound-guided core needle biopsy compared with open biopsy: a new diagnostic approach to salivary gland enlargement in Sjögren’s syndrome? Rheumatology (Oxford). 2021;60(3):1282-90. https://doi.org/10.1093/rheumatology/keaa441

Baer AN, Grader-Beck T, Antiochos B, Birnbaum J, Fradin JM. Ultrasound-guided biopsy of suspected salivary gland lymphoma in Sjogren’s syndrome. Arthritis Care Res (Hoboken). 2021;73(6):849-55. https://doi.org/10.1002/acr.24203

Seror R, Bowman SJ, Brito-Zeron P, Theander E, Bootsma H, Tzioufas A, et al. EULAR Sjögren’s syndrome disease activity index (ESSDAI): a user guide. RMD Open. 2015;1(1):e000022. https://doi.org/10.1136/rmdopen-2014-000022

Giovannini I, Lorenzon M, Manfrè V, Callegher SZ, Pegolo E, Zuiani C, et al. Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren's syndrome with suspected salivary gland lymphoma. RMD Open. 2022;8(1):e001901. https://doi.org/10.1136/rmdopen-2021-001901

Olivier KR, Brown PD, Stafford SL, Ansell SM, Martenson Jr JA. Efficacy and treatment-related toxicity of radiotherapy for early-stage primary non-Hodgkin lymphoma of the parotid gland. Int J Radiat Oncol Biol Phys. 2004;60(5):1510-4. https://doi.org/10.1016/j.ijrobp.2004.05.066

Jamal B. Treatment of parotid non-Hodgkin lymphoma: a meta-analysis. J Glob Oncol. 2018;4:1-6. https://doi.org/10.1200/JGO.17.00071

Feinstein AJ, Ciarleglio MM, Cong X, Otremba MD, Judson BL. Parotid gland lymphoma: prognostic analysis of 2140 patients. Laryngoscope. 2013;123(5):1199-203. https://doi.org/10.1002/lary.23901

Vazquez A, Khan MN, Sanghvi S, Patel NR, Caputo JL, Baredes S, et al. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the salivary glands: a population-based study from 1994 to 2009. Head Neck. 2015;37(1):18-22. https://doi.org/10.1002/hed.23543

Clinicopathological profile of non-hodgkin lymphomas affecting the parotid glands

Authors

DOI:

Keywords:

Abstract

References

Downloads

Published

How to Cite

Issue

Section

License

Submission

Language

Indexers