Correlation between hyposalivation and xerostomia in patients with head and neck cancer
DOI:
https://doi.org/10.5935/2525-5711.20220008Palavras-chave:
saliva, xerostomia, head and neck neoplasmsResumo
Introduction: Saliva plays an important role in maintaining oral homeostasis. However, cancer treatment can induce transient or permanent adverse effects on the salivary glands. Objective: This study aimed to evaluate the correlation between xerostomia and salivary flow velocity (SFV) in patients undergoing antineoplastic treatment for head and neck cancer (HNC), under the Public Health System in the city of Salvador-BA. Materials and Methods: This cross-sectional observational study evaluated medical records of patients diagnosed with HNC and treated by the Oncology Service of the High Complexity Unit in Oncology Nossa Senhora de Fátima - Irmã Dulce Social Works - dental team between January 2019 and March 2020. After anamnesis, stimulated saliva was collected at the 1st and 24th radiotherapy sessions to quantify SFV, and a xerostomia questionnaire was administered for assessments based on a visual analogue scale (VAS). Descriptive statistics were performed, and categorical variables are presented as means, percentages, and coefficients of variation. Results: Medical records of 200 patients were assessed and 16 patients were included in the study. The sociodemographic profile showed a predominance of men (62.50%), aged between 46 and 70 years (56.25%), of mixed ethnicity (43.75%), with incomplete primary education (43.75%), alcoholics (56.25%), and non-smokers (56.25%). Tumor and treatment data showed a predominance of exclusive radiotherapy (50%), location in the larynx (31.25%), and T1/T2 staging (56.25%). The mean SFV of patients was 1.75 mL/min and 0.71 mL/min at the 1st and 24th session, respectively, revealing that irradiation reduced SFV. All domains of the xerostomia scale showed an increase in the means obtained, which indicated worsening of xerostomia between the 1st and 24th sessions. Conclusions: An inverse correlation was observed between the mean VAS scores and SFV in patients with HNC. Further studies to correlate hyposalivation (objective sign) with xerostomia (subjective symptoms) are recommended.
Referências
Costanzo L. Fisiologia. 3a ed. In: Koeppen BM, Stanton BA, eds. Rio de Janeiro: Elsevier; 2005. p. 344-7.
Guyton AC, Hall JE. Tratado de fisiologia médica. 12ª ed. Rio de Janeiro: Elsevier; 2011. p. 817-8.
Freitas DA, Caballero AD, Pereira MM, Oliveira SKM, Silva GP, Hernández CIV. Sequelas bucais da radioterapia de cabeça e pescoço. Rev CEFAC. 2011;13(6):1103-8.
Couto JAM, Lopes FF. A influência da faixa etária na velocidade do fluxo salivar em adultos. RFO. 2010 May/Aug;15(2):135-8.
Lima EDA, Facundo AGL, Carvalho ACL, Silva EB, Gomes CF, Cabral GMP. Saliva e hidratação: importância da quantidade e da qualidade da saliva para manutenção da condição bucal satisfatória em pacientes com paralisia cerebral. Rev Campo Saber. 2017;3(1):101-19.
Ebersole JL, Nagarajan R, Akers D, Miller CS. Targeted salivary biomarkers for discrimination of periodontal health and disease(s). Front Cell Infect Microbiol. 2015 Aug;5(62):1-12.
Falcão DP, Mota LMH, Pires AL, Bezerra ACB. Sialometria: aspectos de interesse clínico. Rev Bras Reumatol. 2013 Dec;53(6):525-31.
Medeiros RSP, Albuquerque ACL, Lima ABL, Barros KMA, Silva DF. Possíveis causas da hipossalivação em pacientes usuários de prótese dental removível. Rev Saúde Ciên Online. 2015;4(3):70-83.
Silva FA, Roussenq SC, Tavares MGS, Souza CPF, Mozzini CB, Benetti M, et al. Perfil epidemiológico dos pacientes com câncer de cabeça e pescoço em um centro oncológico no sul do brasil. Rev Bras Cancerol. 2020 Jan/Mar;66(1):e-08455.
Lima AAS, Figueiredo MAZ, Krapf SMR, Souza FR. Velocidade do fluxo e pH salivar após radioterapia da região decabeça e pescoço. Rev Bras Cancerol. 2004 Oct/Dec;50(4):287-93.
Krasse BO. Risco de cárie: guia prático para controle e assessoramento. 2a ed. São Paulo: Quintessence; 1998.
Thylstrup A, Fejerskov O. Cariologia Clínica. 2a ed. São Paulo: Santos; 1995.
Pai S, Ghezzi EM, Ship JA. Development of a visual analogue scale questionnaire for subjective assessment of salivary dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Mar;91(3):311-6.
Rocha BQC, Eneas L, Oliveira RG, Verner FS, Junqueira RB. Características epidemiológicas de pacientes portadores de neoplasias de cabeça e pescoço submetidos à radioterapia em Juiz de Fora - MG. HU Rev. 2017 Aug;43(1):71-5.
Alvarenga LM, Ruiz MT, Pavarino-Bertelli EC, Ruback MJC, Maniglia JV, Goloni-Bertollo EM. Avaliação epidemiológica de pacientes com câncer de cabeça e pescoço em um hospital universitário do noroeste do estado de São Paulo. Rev Bras Otorrinolaringol. 2008 Feb;74(1):68-73.
Galbiatti ALS, Padovani-Junior JA, Maníglia JV, Rodrigues CDS, Pavarino EC, Goloni-Bertollo EM. Câncer de cabeça e pescoço: causas, prevenção e tratamento. Braz J Otorhinolaryngol. 2013 Apr;79(2):239-47.
Casati MFM, Vasconcelos JA, Vergnhanini GS, Contreiro PF, Graça TB, Kanda JL, et al. Epidemiologia do câncer de cabeça e pescoço no Brasil: estudo transversal de base populacional. Rev Bras Cir Cabeça Pescoço. 2012;41(4):186-91.
Felippu AWD, Freire EC, Silva RA, Guimarães AV, Dedivitis RA. Impacto da demora no diagnóstico e tratamento no câncer de cabeça e pescoço. Braz J Otorhinolaryngol. 2016 Mar/Apr;82(2):140-3.
Silva RGB, Ramos AMPC, Aben-Athar CYUP, Palha IRS, Pinheiro AS, Soares TN. Avaliação da xerostomia em pacientes com câncer de cabeça e pescoço submetidos ao tratamento radioterápico. Rev Cont Saúde. 2017 Jan/Jun;17(32):5-14.
Vissink A, Panders AK, Gravenmade EJ, Vermey A. The causes and consequences of hyposalivation. Ear Nose Throat J. 1988 Mar;67(3):173-6.
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