Co-infection with mucosal leishmaniasis in a patient with leprosy: a case report
DOI:
https://doi.org/10.5327/2525-5711.252%20Palavras-chave:
Leishmaniasis, Leprosy, Coinfection, Case Report, Oral PathologyResumo
Leishmaniasis and leprosy comprise the group of granulomatous diseases. Although both diseases have a known occurrence in Brazil, their concurrent presence is rare, and few cases have been reported in the literature. We report the case of a 46-year-old male patient co-infected with leprosy and mucosal leishmaniasis. Examination revealed an ulcerated lesion on the nose and a lesion with a granulomatous surface on the palate, in addition to spots on the arms and legs. After diagnosis, the patient was treated for co-infection and has been under follow-up for 2 years without signs of recurrence. The diagnosis of leishmaniasis/leprosy co-infection is challenging because of the broad clinical spectrum. Few cases have been reported in the literature and the dentist may play an important role in its detection.
Referências
Nwawka OK, Nadgir R, Fujita A, Sakai O. Granulomatous disease in the head and neck: developing a differential diagnosis. Radiographics. 2014;34(5):1240-56. https://doi.org/10.1148/rg.345130068
World Health Organization. Guidelines for the diagnosis, treatment and prevention of leprosy. New Delhi: WHO; 2017. 87 p.
Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA. Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management. J Am Acad Dermatol. 2015;73(6):911-26; 927-8. https://doi.org/10.1016/j.jaad.2014.09.014
Vernal S, Bueno-Filho R, Gomes CM, Roselino AM. Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: a case series in Southeastern Brazil. Rev Soc Bras Med Trop. 2019;52:e20180172. https://doi.org/10.1590/0037-8682-0172-2018
Mercadante LM, Santos MAS, Pegas ES, Kadunc BV. Leprosy and American cutaneous leishmaniasis coinfection. An Bras Dermatol. 2018;93(1):123-5. https://doi.org/10.1590/abd1806-4841.20186698
Trindade MAB, Silva LLC, Braz LMA, Amato VS, Naafs B, Sotto MN. Post-kala-azar dermal leishmaniasis and leprosy: case report and literature review. BMC Infect Dis. 2015;15:543. https://doi.org/10.1186/s12879-015-1260-x
Di Luca DG, De Andrade PJS, Sales AM, De Menezes VM, Galhardo MCG, Pimentel MIF, et al. Superposition of leprosy and other neglected tropical diseases in the state of Rio de Janeiro: a case series report. Lepr Rev. 2013;84(4):302-7. PMID: 24745129.
Costa JML, Saldanha ACR, Melo LS, Silva AR, Ferreira LA, Costa GC, et al. Cutaneous Leishmaniasis (CL) associated with leprosy: a new and emerging clinico epidemiological entity observed in the northeast of Brazil. Gaz Med Bahia. 2009;79(Supl. 3):95-102.
Azeredo-Coutinho RBG, Matos DCS, Nery JAC, Valete-Rosalino CM, Mendonça SCF. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Braz J Med Biol Res. 2012;45(7):632-6. https://doi.org/10.1590/s0100-879x2012007500073
Ferreira AF, Sousa EA, Márdero García GS, Reis AS, Corona F, Lima MS, et al. Leprosy in the North and Northeast regions of Brazil: an integrated spatiotemporal approach. Trop Med Int Health. 2020;25(2):193-208. https://doi.org/10.1111/tmi.13343
Patrao NAR, Bhat RM, Dandekeri S, Kambil SM. Diffuse cutaneous leishmaniasis in coexistence with leprosy. Int J Dermatol. 2015;54(12):1402-6. https://doi.org/10.1111/ijd.12954
Rijal A, Rijal S, Bhandari S. Leprosy coinfection with kala-azar. Int J Dermatol. 2009;48(7):740-2. https://doi.org/10.1111/j.1365-4632.2009.04018.x
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Copyright (c) 2024 Lorena Sacramento, Larissa Abbehusen Couto, Jean Nunes dos Santos, Sérgio Marcos Arruda, Manoela Carrera
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