Central odontogenic fibroma with giant cell granuloma-like features: a case report and comprehensive literature review
DOI:
https://doi.org/10.5327/2525-5711.277Palabras clave:
Odontogenic Tumors, Central odontogenic fibroma, Giant cell granulomasResumen
Central odontogenic fibroma (COF) is a rare benign tumor from odontogenic mesenchyme, accounting for less than 5% of odontogenic tumors. Central giant cell granuloma (CGCG) is also benign but locally aggressive, featuring multinucleated giant cells in a fibrovascular stroma. Hybrid lesions with features of both COF and CGCG are extremely rare, with fewer than 50 cases reported. This paper presents a case of a hybrid COF-CGCG lesion in a 33-year-old female with an asymptomatic, well-defined unilocular radiolucent lesion between mandibular premolars, causing root resorption and tooth displacement. Histopathological analysis revealed a mixture of inactive odontogenic epithelium and multinucleated giant cells embedded in a dense, collagenized stroma. The patient showed no signs of recurrence after six months of follow-up. This case highlights the rarity and diagnostic challenges of COF-CGCG hybrid lesions, emphasizing the need for further research to understand its pathogenesis and guide management.
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Derechos de autor 2024 Talita de Carvalho Kimura, Renata Sari Precetti, Hélen Kaline Farias Bezerra, Alan Roger dos Santos Silva, Ana Carolina Prado Ribeiro, Pablo Agustin Vargas
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
