Dermoid and epidermoid cysts of the mouth: Clinicopathological and cytokeratin profile
DOI:
https://doi.org/10.5935/2525-5711.20180025Keywords:
Dermoid Cyst, Epidermal Cyst, KeratinsAbstract
Introduction: The mechanisms of cell differentiation and pathogenesis in oral epidermoid cysts and dermoid cyst is poorly know. Objective: To report clinicopathological features and investigate cytokeratin profile of oral epidermoid cysts and dermoid cyst. Material and Methods: Eight cases of epidermoid cysts, 4 of dermoid cyst, and 2 Fordyce granules were included. For analysis of the immunohistochemical expression of cytokeratins (6, 7, 8, 10, 13, 14, 18 and 19), brown staining in the sections examined were defined as positive considering three layers: superficial, intermediate and basal. Results: In dermoid cyst, cytokeratins 7, 8, 9 and 19 were expressed in one case. Cytokeratin 6 was detected in six cases of epidermoid cysts. Cytokeratins 10, 13 and 14 were expressed in all cysts. Cytokeratin 18 was absent in all cysts. Cytokeratins 10 and 14 was observed in Fordyce granules. Cytokeratin 10 was more expressed in peripheral cells and immature sebaceous glands. As these glands became more differentiated, cytokeratin 10 was not detected, while cytokeratin 14 was expressed in mature sebocytes. Cytokeratins 10, 13 and 14 were expressed in the lining mucosa adjacent to Fordyce granules, similar to normal oral mucosal lining. Conclusion: cytokeratin profile is altered in dermoid cyst and epidermoid cysts compared to lining oral mucosa.
References
Sahoo NK, Choudhary AK, Srinivas V, Tomar K. Dermoid cysts of maxillofacial region. Med J Armed Forces India. 2015;71(Suppl 2):S389-94.
Golden BA, Jaskolka M, Ruiz RL. Craniofacial and orbital dermoids in children. Oral Maxillofac Surg Clin North Am. 2012;24:417-25.
Brunet-Garcia A, Lucena-Rivero ED, Brunet-Garcia L, Faubel-Serra M. Cystic mass of the floor of the mouth. J Clin Exp Dent. 2018;10:e287-90.
Lifschitz-Mercer B, Open M, Kushnir I, Czernobilsky B. Epidermoid cyst of the spleen: a cytokeratin profile with comparison to other squamous epithelial. Virchows Arch. 1994;424:213-6.
Kurokawa I, Nishimura K, Hakamada A, Isoda K, Yamanaka K, Mizutani H, et al. Cutaneous dermoid cyst: Cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland. Oncol Rep. 2006;295-9.
Tsuji K, Wato M, Hayashi T, Yasuda N, Matsushita T, Ito T, et al. The expression of cytokeratin in keratocystic odontogenic tumor, orthokeratinized odontogenic cyst, dentigerous cyst, radicular cyst and dermoid cyst. Med Mol Morphol. 2014;47:156-61.
Hoshino M, Inoue H, Kikuchi K, Miyazaki Y, Yoshino A, Hara H, et al. Comparative study of cytokeratin and langerin expression in keratinized cystic lesions of the oral and maxillofacial regions. J Oral Sci. 2015;57:287-94.
Nigam JS, Bharti JN, Nair V, Gargade CB, Deshpande AH, Dey B, et al. Epidermal Cysts: A Clinicopathological Analysis with Emphasis on Unusual Findings. Int J Trichology. 2017;9:108-12.
Kini YK, Kharkar VR, Rudagi BM, Kalburge JV. An unusual occurrence of epidermoid cyst in the buccal mucosa: a case report with review of literature. J Maxillofac Oral Surg. 2013;12:90-3.
Dutta M, Saha J, Biswas G, Chattopadhyay S, Sen I, Sinha R. Epidermoid cysts in head and neck: our experiences, with review of literature. Indian J Otolaryngol Head Neck Surg. 2013;65(Suppl 1):14-21.
dos Santos JN, de Sousa SO, Nunes FD, Sotto MN, de Araújo VC. Altered cytokeratin expression in actinic cheilitis. J Cutan Pathol. 2003;30:237-41.
Dos Santos JN, Oliveira GQ, Gurgel CA, de Souza RO, Sales CB, de Aguiar Pires Valença Neto A, et al. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. J Mol Histol. 2009;40:269-75.
Ravindranath AP, Ramalingam K, Natesan A, Ramani P, Premkumar P, Thiruvengadam C. Epidermoid cysts: an exclusive palatal presentation and a case series. Int J Dermatol. 2009;48:412-5.
Orozco-Covarrubias L, Lara-Carpio R, Saez-De-Ocariz M, Duran-McKinster C, Palacios-Lopez C, Ruiz-Maldonado R. Dermoid cysts: a report of 75 pediatric patients. Pediatr Dermatol. 2013;30:706-11.
Komiyama K, Miki Y, Oda Y, Tachibana T, Okaue M, Tanaka H, et al. Uncommon dermoid cyst presented in the mandible possibly originating from embryonic epithelial remnants. J Oral Pathol Med. 2002;31:184-7.
King RC, Smith BR, Burk JL. Dermoid cyst in the floor of the mouth. Review of the literature and case reports. Oral Surgery Oral Med Oral Pathol. 1994;78:567-76.
Teszler CB, El-Naaj IA, Emodi O, Luntz M, Peled M. Dermoid cysts of the lateral floor of the mouth: A comprehensive anatomo-surgical classification of cysts of the oral floor. J Oral Maxillofac Surg. 2007;65:327-2.
Ueda G, Sawada M, Ogawa H, Tanizawa O, Tsujimoto M. Immunohistochemical study of cytokeratin 7 for the differential diagnosis of adenocarcinomas in the ovary. Gynecol Oncol. 1993;51:219-23.
Yoshimi N, Imai Y, Kakuno A, Tsubura A, Yamanishi K, Kurokawa I. Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification. Int J Dermatol. 2014;53:707-13.
Tomková H, Fujimoto W, Arata J. Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. Am J Dermatopathol. 1997;19:250-3.
Jayasuriya NS, Siriwardena S, Tilakaratne WM, Parthiepan S. Malignant transformation of a long-standing submental dermoid cyst to a carcinosarcoma: a case report. J Med Case Rep. 2017;11:11.
Valach J, Foltán R, Vlk M, Szabo P, Smetana K Jr. Phenotypic characterization of oral mucosa: what is normal? J Oral Pathol Med. 2017;46:834-9.
Koch PJ, Roop DR. The role of keratins in epidermal development and homeostasis-going beyond the obvious. J Invest Dermatol. 2004;123:x-xi.
Moll R. Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell Biochem. 1998;31:205-62.
Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell. 2013;155:1639-51.
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Copyright (c) 1969 Osvaldo Schitini Schitini-Junior, Aguida Cristina Gomes Henriques, Valéria Souza Freitas, Clarissa Araújo Gurgel, Patrícia Ramos Cury, Lélia Batista Souza, Eliabe Almeida dos Santos, Roberto Almeida De Azevedo, Viviane Palmeira da Silva, Jean Nunes dos Santos
This work is licensed under a Creative Commons Attribution 4.0 International License.
