Medication-Related Osteonecrosis of the Jaw Treated by Ozonized Oil: A Case Report
Keywords:
Medication-related osteonecrosis of the jaw, Ozone therapy, AlendronateAbstract
Ozone is an atmospheric gas well-known for its excellent medicinal properties, including antimicrobial activity, immunostimulant and antioxidative. Ozone therapy has been used in dental medicine for treatment of herpetic infection, periodontitis, endodontic infec- tion, acute abscesses and medication-related osteonecrosis of the jaw. This study aims to report the protocol and results of the local use of ozonized oil in the management of patient with medication-related osteonecrosis of the jaw. 81-year-old white female, with exposed bone in the jaw, on left side, and a history of sodium alendronate used to treat osteoporosis. The treatment consisted of ozone therapy with ozonized oil, according to the following protocol: previous mouthwash chlorhexidine 0.12%, Periogard®, for one minute; local application of ozonized oil, Philozon®, with a 5ml syringe no needle, for 10 minutes, re-appliance every two minutes; 10 sessions, once a week each. Between the eighth and ninth treatment week, we observed spontaneous bone sequestration and after six months of follow up, we found local tissue regeneration.
References
Gupta S, Deepa D. Applications of ozone therapy in dentistry. J Oral Res Rev. 2016;8(2):86.
Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques JL. Ozone therapy in medicine and dentistry. J Contemp Dent Pract. 2008 May;9(4):75-84.
Ripamonti CI, Maniezzo M, Boldini S, Pessi MA, Mariani L, Cislaghi E. Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates - preliminary data medical ozone gas insufflation in treating ONJ lesions. J Bone Oncol. 2012 Sep;1(3):81-7.
Agrillo A, Filiaci F, Ramieri V, Riccardi E, Quarato D, Rinna C, et al. Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy. Eur Rev Med Pharmacol Sci. 2012 Nov;16(12):1741-7.
Yarom N, Shapiro CL, Peterson DE, Van Poznak CH, Bohlke K, Ruggiero SL, et al. Medication-related osteonecrosis of the jaw: MASCC/ISOO/ASCO clinical practice guideline. J Clin Oncol. 2019 Sep;37(25):2270-90.
Medeiros CKS, Santos HBP, Rolim LSA, Mororó ABG, Germano AR, Medeiros AMC, et al. Importance of correct management of bisphosphonate-related osteonecrosis of the jaw: case report and literature review. J Oral Diag. 2018;3(1):1-6.
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015 Jan;30(1):3-23.
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, et al. Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Feb;127(2):117-35.
Néri JSV, Lomba E, Karam AM, Reis SRA, Marchionni AMT, Medrado ARAP. Ozone therapy influence in the tissue repair process: a literature review. J Oral Diag. 2017;2(1):1-6.
Ripamonti CI, Cislaghi E, Mariani L, Maniezzo M. Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: preliminary results of a phase I-II study. Oral Oncol. 2011 Mar;47(3):185-90.
Sharma M, Hudson JB. Ozone gas is an effective and practical antibacterial agent. Am J Infect Control. 2008 Oct;36(8):559-63.
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Copyright (c) 1969 Mariana Pinheiro Saldanha, Beatriz Fernandes de-Moura, Renata Ximenes Lins, Beatriz da Rocha Miranda Venturi, Nathalia de Almeida Freire, Mônica Simões Israel
This work is licensed under a Creative Commons Attribution 4.0 International License.
