Mucosal melanoma: report of case involving the oral cavity
DOI:
https://doi.org/10.5935/2525-5711.20200011Keywords:
Melanoma, Mouth mucosa, MouthAbstract
Primary oral mucosal melanoma (POMM) is a rare neoplasm derived from melanocytes, with unknown aetiology, and different presentation than cutaneous melanoma. It mostly affects the palate and maxillary alveolar ridge, with aspects that may mimic different lesions. Microscopically, POMM is characterized by the presence of medium to large atypical melanocytes with diverse morphologies. This neoplasm still presents challenges with regards to an appropriate treatment, and the overall prognosis is dismal. The aim of this report is to show a case of POMM in a 68-year-old female patient, who was diag- nosed due to an extensive and painful oral mass. Although the microscopic diagnosis can be straight-forward for some tumours, most data regarding the biological behaviour of POMM remains uncertain. Detailed microscopic immunohistochemical assessment are essential to elucidate the diagnosis of POMM.
References
Williams MO, Speight P, Wenig BM. Oral mucosal melanoma. In: EI-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, eds. WHO classification of Head and Neck Tumours. 4th Edition. Lyon: IARC; 2017. p. 126-7.
Lourenço SV, Fernandes JD, Hsieh R, Coutinho-Camillo CM, Bologna S, Sangueza M, et al. Head and neck mucosal melanoma: a review. Am J Dermatopathol. 2014 Jul;36(7):578-87.
Green B, Elhamshary A, Gomez R, Rahimi S, Brennan PA. An update on the current management of head and neck mucosal melanoma. J Oral Pathol Med. 2017 Jan;46(7):475-9.
López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, et al. Update on primary head and neck mucosal melanoma. Head Neck. 2016 Jan;38(1):147-55.
Femiano F, Lanza A, Buonaiuto C, Gombos F, Di Spirito F, Cirillo N. Oral malignant melanoma: a review of the literature. J Oral Pathol Med. 2008 Aug;37(7):383-8.
Smith MH, Bhattacharyya I, Cohen DM, Islam NM, Fitzpatrick S, Montague LJ, et al. Melanoma of the oral cavity: an analysis of 46 new cases with emphasis on clinical and histopathologic characteristics. Head Neck Pathol. 2016 Jan;10(3):298-305.
Kaufman HL, Kirkwood JM, Hodi FS, Agarwala S, Amatruda T, Bines SD, et al. The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma. Nat Rev Clin Oncol. 2013 Oct;10(10):588-98.
Rivera RS, Nagatsuka H, Gunduz M, Cengiz B, Gunduz E, Siar CH, et al. C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch. 2008 Jan;452(1):27-32.
Meng D, Carvajal RD. KIT as an oncogenic driver in melanoma: an update on clinical development. Am J Clin Dermatol. 2019 Jun;20(3):315-23.
Ascierto PA, Accorona R, Botti G, Farina D, Fossati P, Gatta G, et al. Mucosal melanoma of the head and neck. Crit Rev Oncol Hematol. 2017 Apr;112:136-52.
Mikkelsen LH, Larsen AC, von Buchwald C, Drzewiecki KT, Prause JU, Heegaard S. Mucosal malignant melanoma - a clinical, oncological, pathological and genetic survey. APMIS. 2016 Jun;124(6):475-86.
Guevara-Canales JO, Gutiérrez-Morales MM, Sacsaquispe-Contreras SJ, Sánchez-Lihón J, Morales-Vadillo R. Malignant melanoma of the oral cavity. Review of the literature and experience in a Peruvian population. Med Oral Patol Oral Cir Bucal. 2012 Mar;17(2):e206-11.
McLean N, Tighiouart M, Muller S. Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma. Oral Oncol. 2008 Apr;44(11):1039-46.
Wand X, Wu HM, Ren GX, Tang J, Guo W. Primary oral mucosal melanoma: advocate a wait-and-see policy in the clinically N0 patient. J Oral Maxillofac Surg. 2012 May;70(5):1192-8.
Lourenço SV, A MS, Sotto MN, Bologna SB, Giacomo TB, Buim ME, et al. Primary oral mucosal melanoma: a series of 35 new cases from South America. Am J Dermatopathol. 2009 Jun;31(4):323-30.
Breik O, Sim F, Wong T, Nastri A, Iseli TA, Wiesenfeld D. Survival outcomes of mucosal melanoma in the head and neck: case series and review of current treatment guidelines. J Oral Maxillofac Surg. 2016 Sep;74(9):1859-71.
Chatzistefanou I, Kolokythas A, Vahtsevanos K, Antoniades K. Primary mucosal melanoma of the oral cavity: current therapy and future directions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jul;122(1):17-27.
Lamichhane NS, An J, Liu Q, Zhang W. Primary malignant mucosal melanoma of the upper lip: a case report and review of the literature. BMC Res Notes. 2015 Sep;8:499.
Mohan M, Sukhadia VY, Pai D, Bhat S. Oral malignant melanoma: systematic review of literature and report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Oct;116(4):e247-54.
Rawal YB, Dodson TB, Bal HS. Oral melanoma: relevance to the dental members. J Am Dent Assoc. 2017 Feb;148(2):113-9.
Topić B, Mašić T, Radović S, Lincender I, Muhić E. Primary oral mucosal melanomas - two case reports and comprehensive literature review. Acta Clin Croat. 2017 Jun;56(2):323-30.
Lydiatt WM, Brandwein-Gensler M, Kraus DH, Mukherji SK, Ridge JA, Shah JP. Mucosal melanoma of the head and neck. In: Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, et al., eds. AJCC - Cancer staging manual. 8th ed. New York: American Joint Committee on Cancer (AJCC)/Springer International Publishing; 2017. p. 163-9.
Ballantyne AJ. Malignant melanoma of the skin of the head and neck. An analysis of 405 cases. Am J Surg. 1970 Oct;120(4):425-31.
Prasad ML, Patel SG, Huvos AG, Shah JP, Busam KJ. Primary mucosal melanoma of the head and neck: a proposal for microstaging localized, stage I (lymph node-negative) tumors. Cancer. 2004 Apr;100(8):1657-64.
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Copyright (c) 1969 Carla Isabelly Rodrigues-Fernandes, Amanda Almeida Leite, Ricardo Salgado de Souza, Pablo Agustin Vargas, Halbert Villalba
This work is licensed under a Creative Commons Attribution 4.0 International License.
