Allergic Contact Stomatitis Associated with Toothpaste Use in Brazil: A Multicenter Retrospective Case Series

Authors

  • Breno Amaral Rocha Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil; Department of Dentistry, Centro Universitário FIPMoc (UNIFIPMoc), Montes Claros, Minas Gerais, Brazil https://orcid.org/0000-0002-3695-9374
  • Guilherme Veloso Ramos Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0002-8543-3360
  • Lilian de Barros Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0002-9204-3539
  • Giovanna Ribeiro Souto Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0003-3617-8794
  • Soraya de Mattos Camargo Grossmann Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0002-8920-3853
  • Paulo Eduardo Alencar Souza Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0001-5166-1982
  • Rodrigo Villamarim Soares Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0001-7698-7532
  • Alan Roger Santos-Silva Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil https://orcid.org/0000-0003-2040-6617
  • Marcio Ajudarte Lopes Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil https://orcid.org/0000-0001-6677-0065
  • Thaís Cristina Esteves-Pereira Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil https://orcid.org/0000-0002-4559-9788
  • Maria Cássia Ferreira de Aguiar Department of Oral Pathology and Surgery, School of Dentistry, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0001-5134-3466
  • Hyago Portela Figueiredo Department of Oral Pathology and Surgery, School of Dentistry, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0003-4315-9823
  • Rafael Aguiar de Sousa Department of Oral Pathology and Surgery, School of Dentistry, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0009-0008-6217-1418
  • João Adolfo Costa Hanemann School of Dentistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil https://orcid.org/0000-0002-3865-905X
  • Martinho Campolina Rebello Horta Graduate Program in Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0003-0192-5614

DOI:

https://doi.org/10.5327/2525-5711.433

Keywords:

Toothpastes, Hypersensitivity, Mouth Mucosa, Oral Medicine, Public Health

Abstract

Objective: This study describes the clinical features and outcomes of Brazilian patients diagnosed with suspected allergic contact stomatitis (ACS) after using a newly introduced commercial toothpaste formulation. Methods: This multicenter retrospective case series included six patients evaluated between January and May 2025 by Oral Medicine services at four universities. Inclusion criteria comprised clinical signs and/or symptoms compatible with ACS, recent use of a new Colgate-Palmolive toothpaste formulation containing stannous fluoride, and no reported exposure to other allergens. Clinical data retrieved from patient records underwent descriptive analysis. Results: All patients presented acute oral symptoms including burning, pain, dysphagia, and dyslalia. Clinical signs included erythematous macules, white plaques, desquamation, vesicles, erosions and ulcers affecting different oral sites. Lesions resolved within 4 to 29 days after toothpaste discontinuation, with or without pharmacologic intervention. No cases required biopsy or patch testing. In all cases, the temporal relationship and remission following toothpaste withdrawal supported the diagnosis of ACS. Conclusion: This study highlights a potential association between toothpaste formulations and ACS. Given the complexity of toothpaste formulations and the absence of allergological testing, the causative substance remains uncertain. Clinicians should consider ACS in patients presenting with unexplained oral lesions and recent changes in oral hygiene products.

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Published

2026-02-20

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1.
Rocha BA, Ramos GV, de Barros L, Ribeiro Souto G, Grossmann S de MC, Souza PEA, et al. Allergic Contact Stomatitis Associated with Toothpaste Use in Brazil: A Multicenter Retrospective Case Series. J Oral Diagn [Internet]. 2026 Feb. 20 [cited 2026 Apr. 11];. Available from: https://joraldiagnosis.com/revista/article/view/433

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Copyright (c) 2026 Breno Amaral Rocha , Guilherme Veloso Ramos , Lilian de Barros, Giovanna Ribeiro Souto , Soraya de Mattos Camargo Grossmann, Paulo Eduardo Alencar Souza, Rodrigo Villamarim Soares , Alan Roger Santos-Silva , Marcio Ajudarte Lopes , Thaís Cristina Esteves-Pereira , Maria Cássia Ferreira de Aguiar , Hyago Portela Figueiredo, Rafael Aguiar de Sousa , João Adolfo Costa Hanemann , Martinho Campolina Rebello Horta

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