Therapeutic challenges of recurrent oral squamous cell carcinomas in fanconi anemia: a case report

Camila Adriane Leffa Rosa; Waleska Tychanowicz Kolodziejwski; Priscila Queiroz Mattos da Silva; Angela Maira  Guimarães; Juliana Lucena  Schussel

doi:10.5327/2525-5711.378

Authors

Camila Adriane Leffa Rosa Federal University of Paraná, Hospital Care, Dentist – Curtitiba (PR), Brazil. https://orcid.org/0000-0001-6379-0976
Waleska Tychanowicz Kolodziejwski Federal University of Paraná, Hospital Care, Dentist – Curtitiba (PR), Brazil. https://orcid.org/0000-0001-6301-8767
Priscila Queiroz Mattos da Silva Federal University of Paraná, Hospital Care, Dentist – Curtitiba (PR), Brazil. https://orcid.org/0000-0003-1612-5417
Angela Maira Guimarães Federal University of Paraná, Hospital Care, Dentist – Curtitiba (PR), Brazil. https://orcid.org/0000-0002-0541-3352
Juliana Lucena Schussel Federal University of Paraná, Hospital Care, Dentist – Curtitiba (PR), Brazil. https://orcid.org/0000-0001-5204-0782

DOI:

https://doi.org/10.5327/2525-5711.378

Keywords:

Carcinoma, Oral cancer, Fanconi Anemia

Abstract

Fanconi anemia (FA) is a rare, inherited recessive syndrome characterized by progressive bone marrow failure and a predisposition to developing malignant neoplasms. A male patient diagnosed with Fanconi anemia underwent a haploidentical hematopoietic cell transplantation (HCT) at 10 years of age. Eleven years later, he developed his first malignant lesion on the lower lip. Unfortunately, the patient experienced rapid recurrences of squamous cell carcinoma (SCC), initially in the oral cavity, with subsequent progression to the maxillary sinus, sphenoid wing, and right orbital floor. The aggressive nature of the disease, coupled with limited treatment options, ultimately led to a poor prognosis and the patient subsequently passed away. This case underscores the severity of Fanconi anemia, demonstrated by the emergence of multiple lesions in diverse locations and their rapid progression in a young patient. It highlights the complexity and significant challenges in managing malignant lesions in patients with FA.

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