Clear cell variant of calcifying epithelial odontogenic tumor: an unusual case report
DOI:
https://doi.org/10.5327/2525-5711.279Keywords:
Calcifying epithelial odontogenic tumor, Clear cell, Mandible, Pindborg tumorAbstract
The calcifying epithelial odontogenic tumor (CEOT), also known as Pindborg tumor, is a rare odontogenic neoplasm originating from epithelial tissue. The presence of clear cells within CEOT is an unusual finding, indicating a variant with distinctive histopathological features and possible clinical implications. This study presents a case report of a clear cell variant of CEOT in a 36-year-old male patient with painless swelling in the anterior mandible. The occurrence of clear cells in CEOT is uncommon and may mimic other clear cell tumors. Therefore, the identification of amyloid-like deposits and calcifications is essential in confirming the diagnosis of clear cell variant of CEOT.
References
Pindborg JJ. Calcifying epithelial odontogenic tumour. Acta Pathol Microbiol Scand 1955;111:71.
Chrcanovic BR, Gomez RS. Calcifying epithelial odontogenic tumor: an updated analysis of 339 cases reported in the literature. J Craniomaxillofac Surg. 2017;45(8):1117-23. https://doi.org/10.1016/j.jcms.2017.05.007
Arruda JAA, Arantes DAC, Schuch LF, Mosconi C, Abreu LG, Andrade BAB, et al. A rare case of an aggressive clear cell variant of calcifying epithelial odontogenic tumor in the posterior maxilla. Int J Surg Pathol. 2020;28(5):526-35. https://doi.org/10.1177/1066896920901755
Anavi Y, Kaplan I, Citir M, Calderon S. Clear-cell variant of calcifying epithelial odontogenic tumor: clinical and radiographic characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(3):332-9. https://doi.org/10.1067/moe.2003.8
Cheng YSL, Wright JM, Walstad WR, Finn MD. Calcifying epithelial odontogenic tumour showing microscopic features of potential malignant behavior. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93(3):287-95. https://doi.org/10.1067/moe.2002.121991
Siriwardena BSMS, Speight PM, Franklin CD, Abdelkarim R, Khurram SA, Hunter KD. CEOT variants or entities: time for a rethink? A case series with review of the literature. Head Neck Pathol. 2021;15(1):186-201. https://doi.org/10.1007/s12105-020-01200-9
Morais HGF, Silva WR, Andrade ACM, Silva NS, Xerez MC, Santos JWM, et al. Pindborg tumor associated with a supernumerary tooth: a case report. Autops Case Rep. 2022;12:e2021358. https://doi.org/10.4322/acr.2021.358
Peacock ZS, Cox D, Schmidt BL. Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor. Oral Oncol. 2010;46(5):387-92. https://doi.org/10.1016/j.oraloncology.2010.02.023
Shimura M, Nakashiro KI, Sawatani Y, Hasegawa T, Kamimura R, Izumi S, et al. Whole exome sequencing of SMO, BRAF, PTCH1 and GNAS in odontogenic diseases. In Vivo. 2020;34(6):3233-40. https://doi.org/10.21873/invivo.12159
Sousa SF, Diniz MG, França JA, Pereira TSF, Moreira RG, Santos JN, et al. Cancer genes mutation profiling in calcifying epithelial odontogenic tumour. J Clin Pathol. 2018;71(3):279-83. https://doi.org/10.1136/jclinpath-2017-204813
Hicks MJ, Flaitz CM, Wong ME, McDaniel RK, Cagle PT. Clear cell variant of calcifying epithelial odontogenic tumor: case report and review of the literature. Head Neck. 1994;16(3):272-7. https://doi.org/10.1002/hed.2880160311
Li Y, Wan K, Wang M, Cui G, Chen B, Yu L, et al. Giant calcifying epithelial odontogenic tumor after I-125 seed implantation: a case report. Heliyon. 2023;9(7):e17087. https://doi.org/10.1016/j.heliyon.2023.e17087
Kaur T, Dhawan A, Bhullar RS, Gupta S. Cemento-ossifying fibroma in maxillofacial region: a series of 16 cases. J Maxillofac Oral Surg. 2021;20(2):240-5. https://doi.org/10.1007/s12663-019-01304-y
Salvi AS, Patankar S, Desai K, Wankhedkar D. Focal cemento-osseous dysplasia: a case report with a review of literature. J Oral Maxillofac Pathol. 2020;24(Suppl 1):S15-S18. https://doi.org/10.4103/jomfp.JOMFP_349_19
Germanier Y, Bornstein MM, Stauffer E, Buser D. Calcifying epithelial odontogenic (pindborg) tumor of the mandible with clear cell component treated by conservative surgery: report of a case. J Oral Maxillofac Surg. 2005;63(9):1377-82. https://doi.org/10.1016/j.joms.2005.05.298
Turatti E, Brasil J, Andrade BAB, Romañach MJ, Almeida OP. Clear cell variant of calcifying epithelial odontogenic tumor: case report with immunohistochemical findings. J Clin Exp Dent. 2015;7(1):e163-6. https://doi.org/10.4317/jced.51995
Patankar S, Choudhari S, Sharma S, Dhumal S. Noncalcifying clear-cell variant of calcifying epithelial odontogenic tumor: a case report and review. J Oral Maxillofac Pathol. 2021;25(1):204. https://doi.org/10.4103/jomfp.JOMFP_212_20
Jain A, Shetty DC, Juneja S, Narwal N. Molecular characterization of clear cell lesions of head and neck. J Clin Diagn Res. 2016;10(5):ZE18-23. https://doi.org/10.7860/JCDR/2016/14394.7867
Loyola AM, Cardoso SV, Faria PR, Servato JPS, Paulo LFB, Eisenberg ALA, et al. Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120(4):483-96. https://doi.org/10.1016/j.oooo.2015.06.005
Rammal R, Batson B, Spector ME, Chiosea, SI, Seethala RR. Acinic cell carcinoma with high-grade squamoglandular and chondrosarcomatous transformation mimicking 'carcinosarcoma ex-pleomorphic adenoma': a wrinkle in the proposed nomenclature revision for sarcomatoid salivary gland neoplasms. Head Neck Pathol. 2024;18(1):44. https://doi.org/10.1007/s12105-024-01650-5
Kudva R, Nayal B, Kantipudi S, Ray S. Metastatic renal cell carcinoma of the buccal mucosa masquerading as a salivary gland neoplasm. J Oral Maxillofac Pathol. 2016;20(3):547. https://doi.org/10.4103/0973-029X.190967
Goode RK. Calcifying epithelial odontogenic tumor. Oral Maxillofac Surg Clin North Am. 2004;16(3):323-31. https://doi.org/10.1016/j.coms.2004.03.002
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Kallana Mezzomo Faccin, Heron Stähelin, Thiago Pires Claudio, Natalia Cristina Trentin Bordignon, Elena Riet Correa Rivero, Ricardo Luiz Cavalcanti Albuquerque-Junior, Rogerio Gondak
This work is licensed under a Creative Commons Attribution 4.0 International License.
