Clinicopathological and immunohistochemical study of canalicular adenoma

Marianne de Vasconcelos Carvalho; Juan Manuel Arteaga Legarrea; Ana Carolina Prado Ribeiro; Felipe Paiva Fonseca; Bruno Augusto Benevenuto de Andrade; Oslei Paes de Almeida; Márcio Ajudarte Lopes; Pablo Agustin Vargas

doi:10.5327/2525-5711.259

Authors

Marianne de Vasconcelos Carvalho University of Pernambuco – Recife (PE), Brazil. https://orcid.org/0000-0002-6815-5696
Juan Manuel Arteaga Legarrea Universidade Federal de Minas Gerais, Oral Surgery and Oral Pathology – Belo Horizonte, Brazil. https://orcid.org/0000-0003-4637-4617
Ana Carolina Prado Ribeiro Universidade de São Paulo, Faculdade de Medicina, Instituto do Câncer do Estado de São Paulo, Dental Oncology Service – São Paulo (SP), Brazil. https://orcid.org/0000-0002-0127-7998
Felipe Paiva Fonseca Universidade Federal de Minas Gerais, Oral Surgery and Oral Pathology – Belo Horizonte, Brazil. https://orcid.org/0000-0002-6657-4547
Bruno Augusto Benevenuto de Andrade Universidade Federal do Rio de Janeiro, Oral Diagnosis and Pathology – Rio de Janeiro (RJ), Brazil. https://orcid.org/0000-0002-3259-606X
Oslei Paes de Almeida University of Campinas, Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0003-2002-8003
Márcio Ajudarte Lopes University of Campinas, Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0001-6677-0065
Pablo Agustin Vargas University of Campinas, Oral Diagnosis – Piracicaba (SP), Brazil. https://orcid.org/0000-0003-1840-4911

DOI:

https://doi.org/10.5327/2525-5711.259

Keywords:

Salivary gland tumors, canalicular adenoma, immunohistochemistry

Abstract

Objective: To evaluate the clinicopathological and immunohistochemical features of an original series of canalicular adenoma.

Methods: Cases diagnosed as canalicular adenoma from a single center were retrospectively retrieved and clinical data collected from patients’ charts. The histopathological features of all cases were reviewed and a large immunohistochemical panel carried out.

Results: Eleven cases were collected, and no gender predilection was seen. A painless upper lip nodule was the most frequent clinical presentation. All cases presented the single-layer epithelial arrangement of tumor cells in a loose stroma. It was found an increased expression of low-weight cytokeratins, absence of myogenic markers, variable positivity for vimentin, S100 and GFAP, cytoplasmic and membrane reactivity for β-catenin and a strong CD34 positivity, whereas no lymphatic vessel was identified using D2-40 antibody.

Conclusion: Canalicular adenoma is composed of luminal epithelium with strong expression of low-weight cytokeratins, and peripheral expression of β-catenin may be involved in the architectural maintenance of the tumor.

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Clinicopathological and immunohistochemical study of canalicular adenoma

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