CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF CANALICULAR ADENOMA

Authors

  • Juan Manuel Arteaga Legarrea Federal University of Minas Gerais
  • Marianne de Vasconcelos Carvalho School of Dentistry, University of Pernambuco (UPE), Recife, Pernambuco, Brazil
  • Ana Carolina Prado Ribeiro Dental Oncology Service, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
  • Felipe Paiva Fonseca Department of Oral Surgery and Oral Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • Bruno Augusto Benevenuto de Andrade Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Oslei Paes de Almeida Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil
  • Márcio Ajudarte Lopes Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil
  • Pablo Agustin Vargas Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil

DOI:

https://doi.org/10.5327/2525-5711.259

Keywords:

Salivary gland tumors, canalicular adenoma, immunohistochemistry

Abstract

Objective: To evaluate the clinicopathological and immunohistochemical features of an original series of canalicular adenoma.

Study design: Cases diagnosed as canalicular adenoma from a single center were retrospectively retrieved and clinical data collected from patients’ charts. The histopathological features of all cases were reviewed and a large immunohistochemical panel carried out.

Results: Eleven cases were collected, and no gender predilection was seen. A painless upper lip nodule was the most frequent clinical presentation. All cases presented the single-layer epithelial arrangement of tumor cells in a loose stroma. It was found an increased expression of low-weight cytokeratins, absence of myogenic markers, variable positivity for vimentin, S100 and GFAP, cytoplasmic and membrane reactivity for β-catenin and a strong CD34 positivity, whereas no lymphatic vessel was identified using D2-40 antibody. 

Conclusion: Canalicular adenoma is composed of luminal epithelium with strong expression of low-weight cytokeratins, and peripheral expression of β-catenin may be involved in the architectural maintenance of the tumor.

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Published

2024-10-31

How to Cite

1.
Arteaga Legarrea JM, de Vasconcelos Carvalho M, Prado Ribeiro AC, Paiva Fonseca F, Benevenuto de Andrade BA, Paes de Almeida O, et al. CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF CANALICULAR ADENOMA. J Oral Diagn [Internet]. 2024 Oct. 31 [cited 2024 Nov. 15];. Available from: https://joraldiagnosis.com/revista/article/view/259

Issue

2024: In Press

Section

Original Article

License

Copyright (c) 2024 Juan Manuel Arteaga Legarrea, Marianne de Vasconcelos Carvalho, Ana Carolina Prado Ribeiro, Felipe Paiva Fonseca, Bruno Augusto Benevenuto de Andrade, Oslei Paes de Almeida, Márcio Ajudarte Lopes, Pablo Agustin Vargas

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This work is licensed under a Creative Commons Attribution 4.0 International License.