Crohn's disease: Low-Level Laser Therapy (LLLT) as an adjuvant treatment of oral lesions

Authors

  • Cíntia de Souza Alferes Araújo Universidade Paranaense https://orcid.org/0000-0001-6028-2589
  • Carolina Eurich Mazur Universidade Federal do Paraná
  • Vitória Maria de-Melo Nardino Universidade Paranaense
  • Hanagleicy Souza Universidade Paranaense
  • Roberta Targa Stramandinoli-Zanicotti Universidade Federal do Paraná
  • Mirella Lindoso Gomes Campos Universidade do Sagrado Coraçao
  • Edimar Rafael Oliveira Universidade Federal do Paraná
  • José Miguel Amenábar Universidade Federal do Paraná

DOI:

https://doi.org/10.5935/2525-5711.20180026

Keywords:

Crohn Disease, Mouth, Laser Therapy

Abstract

Classified as a chronic inflammatory bowel disease, Crohns disease (CD) has a multifactorial etiology. Individual with CD can present signs/symptoms such as abdominal pain, fever, diarrhea with a serious risk of hemorrhagic progression, weight loss, anemia and malnutrition. Extra-intestinal complications of CD such as at mouth are probable in some cases. In the mouth, it may presents ulcers, verrucous lesions, swelling of the lips, recurrent aphthous stomatitis, and predisposition to fungal, bacterial and viral infections. In view of the patient´s clinical condition, oral manifestations variable, painful symptomatology and challenge in the choice of oral lesions treatment, this study presents a case of Chron´s Disease´s oral manifestations and its management with Low-Level Laser Therapy (LLLT).

Author Biographies

Cíntia de Souza Alferes Araújo, Universidade Paranaense

Odontologia

Carolina Eurich Mazur, Universidade Federal do Paraná

Departamento de Estomatologia

Vitória Maria de-Melo Nardino, Universidade Paranaense

Odontologia

Hanagleicy Souza, Universidade Paranaense

Odontologia

Roberta Targa Stramandinoli-Zanicotti, Universidade Federal do Paraná

Departamento de Estomatologia

Mirella Lindoso Gomes Campos, Universidade do Sagrado Coraçao

Curso de Odontologia

Edimar Rafael Oliveira, Universidade Federal do Paraná

Departamento de Estomatologia

José Miguel Amenábar, Universidade Federal do Paraná

Departamento de Estomatologia

References

Gajendran M, Loganathan P, Catinella AP, Hashash JG. A comprehensive review and update on Crohn's disease. Dis Mon. 2018;64:20-57. DOI: 10.1016/j.disamonth.2017.07.001

Feuerstein JD, Cheifetz AS. Crohn Disease: Epidemiology, Diagnosis, and Management. Mayo Clin Proc. 2017;92:1088- 103. DOI: 10.1016/j.mayocp.2017.04.010

Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn's disease. Lancet. 2017;389:1741-55. DOI: 10.1016/S0140- 6736(16)31711-1

Lucas López R, Grande Burgos MJ, Gálvez A, Pérez Pulido R. The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review. APMIS. 2017;125:3-10. DOI: 10.1111/apm.12609

Głowacka B, Radwan-Oczko M. Dental perspective on Crohn's disease: literature review. Wiad Lek. 70:860-4.

Aguirre A, Nugent CA. Oral Manifestation of Crohn's Disease. N Engl J Med. 2015;373:1250. DOI: 10.1056/NEJMicm1413715

O'Neill I, Scully C. Biologics in oral medicine: oral Crohn's disease and orofacial granulomatosis. Oral Dis. 2012;18:633-8. DOI: 10.1111/j.1601-0825.2012.01918.x

Nishikawa J, Hosokawa A, Sugiyama T. Palatal ulcer as an initial manifestation of Crohn's Disease. Clin Gastroenterol Hepatol. 2014;12:e115-6. DOI: 10.1016/j.cgh.2014.07.026

Szczeklik K, Pytko-Polończyk J, Cibor D, Owczarek D, Mach T. Oral mucosa lesions in patients with active Crohn's disease - a prospective study. Przegl Lek. 2017;74:57-61.

Mortada I, Leone A, Gerges Geagea A, Mortada R, Matar C, Rizzo M, et al. Oral manifestations of inflammatory bowel disease. J Biol Regul Homeost Agents. 2017;31:817-21.

Giller JP, Vinciguerra M, Heller A, Kunken FR, Kahn E. Treatment of gingival Crohn's disease with laser therapy. N Y State Dent J. 1997;63:32-5.

Andrade Fdo S, Clark RM, Ferreira ML. Effects of low-level laser therapy on wound healing. Rev Col Bras Cir. 2014;41:129- 33. DOI: 10.1590/S0100-69912014000200010

Gionchetti P, Calabrese C, Rizzello F. Inflammatory Bowel Diseases and Spondyloarthropathies. J Rheumatol Suppl. 2015;93:21-3. DOI: 10.3899/jrheum.150628

Mentzer A, Goel R, Elliott T, Campbell H, Hullah E, Patel P, et al. Azathioprine is effective for oral involvement in Crohn's disease but not for orofacial granulomatosis alone. J Oral Pathol Med. 2016;45:312-8. DOI: 10.1111/jop.12379

Tomazoni EI, Benvegnú DM. Symptoms of anxiety and depression, and quality of life of patients with Crohn's disease. Arq Gastroenterol. 2018;55:148-53. DOI: 10.1590/S0004-2803.201800000-26

Eckel A, Lee D, Deutsch G, Maxin A, Oda D. Oral manifestations as the first presenting sign of Crohn's disease in a pediatric patient. J Clin Exp Dent. 2017;9:e934-e938. DOI: 10.4317/jced.53914

Laranjeira N, Fonseca J, Meira T, Freitas J, Valido S, Leitao J. Oral mucosa lesions and oral symptoms in inflammatory bowel disease patients. Arq Gastroenterol. 2015;52:105-10. DOI: 10.1590/S0004-28032015000200006

Laube R, Liu K, Schifter M, Yang JL, Suen MK, Leong RW. Oral and upper gastrointestinal Crohn's disease. J Gastroenterol Hepatol. 2018;33:355-64. DOI: 10.1111/jgh.13866

Muhvić-Urek M, Tomac-Stojmenović M, Mijandrusić-Sinčić B. Oral pathology in inflammatory bowel disease. World J Gastroenterol. 2016;22:5655-67. DOI: 10.3748/wjg.v22.i25.5655

Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Sonis ST, Elad S, et al. Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations. Support Care Cancer. 2016;24:2781-92. DOI: 10.1007/s00520-016-3152-z

Seksik P, Cosnes J, Sokol H, Nion-Larmurier I, Gendre JP, Beaugerie L. Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine. Aliment Pharmacol Ther. 2009;29:1106-13. DOI: 10.1111/j.1365-2036.2009.03973.x

Haag LM, Hofmann J, Kredel LI, Holzem C, Kühl AA, Taube ET, et al. Herpes Simplex Virus Sepsis in a Young Woman with Crohn's Disease. J Crohns Colitis. 2015;9:1169-73. DOI: 10.1093/ecco-jcc/jjv149

Downloads

Published

2019-01-15

How to Cite

1.
Araújo C de SA, Mazur CE, Nardino VM de-M, Souza H, Stramandinoli-Zanicotti RT, Campos MLG, et al. Crohn’s disease: Low-Level Laser Therapy (LLLT) as an adjuvant treatment of oral lesions. J Oral Diagn [Internet]. 2019 Jan. 15 [cited 2024 Nov. 15];4:1-5. Available from: https://joraldiagnosis.com/revista/article/view/117

Issue

Section

Original Article