Anaplastic Large Cell Lymphoma CD30+ ALK- in the Oral Cavity as a Primary Manifestation in HIV+ Patient: Case Report
DOI:
https://doi.org/10.5935/2525-5711.20190010Keywords:
Lymphoma, HIV, Mouth, NeoplasmsAbstract
Anaplastic large cell lymphoma (ALCL) is a rare subtype of T-cell lymphoma that may involve mucocutaneous sites, in primary form, or secondary to systemic disease. It is a systemic malignancy characterized by an extranodal phenotype that rarely occurs in the oral cavity as the first manifestation of acquired immunodeficiency syndrome. In the primary forms, ALCL stands out for its favorable prognosis, being important to differentiate them clinically from the secondary ones, which have a rapid and aggressive evolution. For its diagnosis, it requires a rigorous physical and clinical examination and a duly oriented anatomopathological and immunohistochemical evaluation. In the present work, a clinical case of ALCL secondary to HIV is presented, detailing clinical characteristics, anatomopathological description, immunohistochemical profile and evolution against treatment.
References
Narwal A, Yadav AB, Prakash S, Gupta S. Anaplastic lymphoma kinase negative anaplastic large cell lymphoma of hard palate as first clinical manifestation of acquired immune deficiency syndrome. Contemp Clin Dent. 2016; 7:114-7.
Beral V, Peterman T, Berkelman R, Jaffe H. AIDS-associated non-Hodgkin lymphoma. Lancet. 1991; 337:805-9.
O’leary H, Savage KJ. The spectrum of peripheral T-cell lymphomas. Curr Opin Hematol. 2009; 16:292-8.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. 4 ed. Lyon: IARC; 2008.
De Leval L, Gaulard P. CD30+ lymphoproliferative disorders. Haematologica. 2010; 10:1627-30.
Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005; 10:3768-85.
Villa A, Mariani U, Villa F. T-cell lymphoma of the oral cavity: a case report. Aust Dent J. 2010; 2:203-6.
Eros N, Marschalko M, Lorincz A, Hársing J, Csomor J,Szepesi A, et al. CD30-positive anaplastic large T-cell lymphoma of the tongue. J Eur Acad Dermatol Venereol. 2009; 2:231-2.
Agarwal M, Shenjere P, Blewitt RW, Hall G, Sloan P, Pigadas N, et al. CD30-positive T-cell lymphoproliferative disorder of the oral mucosa - an indolent lesion: report of 4 cases. Int J Surg Pathol. 2008; 3:286-90.
Savarrio L, Gibson J, Dunlop DJ. Spontaneous regression of an anaplastic large cell lymphoma in the oral cavity: first reported case and review of the literature. Oral Oncol. 1999; 6:609-13.
Wang W, Cai Y, Sheng W, Lu H, Li X. The spectrum of primary mucosal CD30-positive T-cell lymphoproliferative disorders of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 117:96-104.
Sciallis AP, Law ME, Inwards DJ, McClure RF, Macon WR, Kurtin PJ, et al. Mucosal CD30-positive T-cell lymphoproliferations of the head and neck show a clinicopathologic spectrum similar to cutaneous CD30-positive T-cell lymphoproliferative disorders. Mod Pathol. 2012; 25:983-92.
Matsumoto N, Ohki H, Mukae S, Amano Y, Harada D, Nashimura S, et al. Anaplastic large cell lymphoma in gingiva: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 4:29-34
Grandhi A, Boros AL, Berardo N, Reich RF, Freedman PD. Two cases of CD30+, anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma with oral manifestations. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 2:41-7.
Segura S, Romero D, Mascaró JM, Colomo L, Ferrando J, Estrach T. Eosinophilic ulcer of the oral mucosa: another histological simulator of CD30+ lymphoproliferative disorders. Br J Dermatol. 2006; 2:460-3.
Rosenberg A, Biesma DH, Sie-Go DM, Slootweg PJ. Primary extranodal CD30+ T-cell non-Hodking’s lymphoma of the oral mucosa: Report of two cases. Int J Oral Maxillofac Surg. 1996; 1:57-9.
Ferreri AJ, Govi S, Pileri SA, Savage KJ. Anaplastic large cell lymphoma, ALK-negative. Crit Rev Oncol Hematol. 2013; 85(2):206-15.
Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, et al. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. 2014; 124:1473-80.
Clavijo MM, Garate G, Aizpurua F, Mahuad C, Vicente A, Casali C, et al. Use of brentuximab vedotin for refractory ALK negative anaplastic large cell lymphoma 20. Savage KJ, Harris NL, Vose JM, et al. ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different
from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project. Blood. 2008; 111:5496-504.
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Copyright (c) 1969 Nicolás Leonardi, Ricardo Christían Caciva, Eduardo David Piemonte, Martín Brusa, Rubén Sambuelli, Adrián Allende, René Luis Panico
This work is licensed under a Creative Commons Attribution 4.0 International License.
